CBTRUS Statistical Report:
Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2018-2022
This report was prepared by the CBTRUS Scientific Principal Investigator, Quinn T. Ostrom, Ph.D., M.P.H. and her research team from Duke University School of Medicine in collaboration with CBTRUS Research and Policy Coordinator Mackenzie Price, M.P.H. and CBTRUS President and Chief Mission Officer Carol Kruchko, collectively known as the CBTRUS Team.
The CBTRUS data presented in this report were provided through an agreement with the Centers for Disease Control and Prevention’s (CDC) National Program of Cancer Registries (NPCR). In addition, CBTRUS used data from the National Cancer Institute’s (NCI) Surveillance, Epidemiology, and End Results (SEER) Program. CBTRUS acknowledges and appreciates these contributions to this report and to cancer surveillance in general and in particular to the efforts of the oncology data specialists, the central cancer registries, and the staff from the NPCR and SEER programs whose efforts to collect accurate and complete data have made this report possible.
We are also grateful for our Consulting Neuropathologists who answered our questions and provided feedback throughout the year, to our Board of Directors and Advisors, and especially Dr. Annette M. Molinaro, Dr. David J. Cote, Dr. Al Musella, Dr. Kristin A. Waite, and Mary Elizabeth O’Neil, M.P.H., who reviewed this report.
Sources of geographic population-based cancer incidence data for 2018-2022 included in this report are from the following 52 central cancer registries (CCRs):
| Alabama | HawaiiSEER | Michigan | North Carolina | Texas |
| Alaska | Idaho | Minnesota | North Dakota | Utah |
| Arizona | Illinois | Mississippi | Ohio | Vermont |
| Arkansas | Indiana | Missouri | Oklahoma | Virginia |
| California | IowaSEER | Montana | Oregon | Washington |
| Colorado | Kansas | Nebraska | Puerto Rico | West Virginia |
| ConnecticutSEER | Kentucky | Nevada | Pennsylvania | Wisconsin |
| Delaware | Louisiana | New Hampshire | Rhode Island | Wyoming |
| District of Columbia | Maine | New Jersey | South Carolina | |
| Florida | Maryland | New MexicoSEER | South Dakota | |
| Georgia | Massachusetts | New York | Tennessee |
(SEER) Data were obtained from the SEER research data files for these population-based cancer registries for incidence calculations. All other population-based cancer registry data provided by the NPCR, which may include registries for which data are also available through SEER.
Sources of geographic population-based cancer survival data for 2001-2021 included in the 2025 CBTRUS Report are from 43 CCRs of the NPCR Program:
| Alabama | Illinois | Minnesota | North Carolina | Texas |
| Arizona | Indiana | Mississippi | North Dakota | Utah |
| Arkansas | Kansas | Missouri | Ohio | Vermont |
| California | Kentucky | Montana | Oklahoma | Washington |
| Colorado | Louisiana | Nebraska | Oregon | West Virginia |
| Delaware | Maine | Nevada | Pennsylvania | Wisconsin |
| District of Columbia | Maryland | New Hampshire | Rhode Island | Wyoming |
| Georgia | Massachusetts | New Jersey | South Carolina | |
| Idaho | Michigan | New York | Tennessee |
In addition, CBTRUS used data from the research data files of the NCI’s SEER Program and the National Center for Health Statistics National Vital Statistics System.
Citation: Mackenzie Price, M.P.H., Christine Ann Pittman Ballard, M.P.H., Julia R. Beneditti, M.B.S., Carol Kruchko, B.A., Jill S. Barnholtz-Sloan, Ph.D., and Quinn T. Ostrom, Ph.D., M.P.H., CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2018-2022, Neuro-Oncology, Volume 27, Issue Supplement 4, October 2025, Pages vi1-vi66